Basic Information
| LncRNA/CircRNA Name | ARAP1-AS1 |
| Synonyms | NA |
| Region | GRCh38_11:72685075-72693808 |
| Ensemble | ENSG00000256007 |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, other |
| Sample | BCa tissues and cell lines (T24, 5637, EJ, TCC, 253J and J82) |
| Expression Pattern | up-regulated |
| Function Description | ARAP1-AS1 was enriched in the cytoplasm of BCa cells, suggesting that ARAP1-AS1 might act as a ceRNA to regulate gene expression and biological processes in bladder cancer. It was certified that ARAP1-AS1 can bind with miR-4735-3p in BCa cells. Moreover, functional assays supported the hypothesis that miR-4735-3p is a tumor suppressor in BCa. Additionally, NOTCH2 mRNA could be targeted by miR-4735-3p in BCa cells. |
| Pubmed ID | 30404578 |
| Year | 2019 |
| Title | Long non-coding RNA ARAP1-AS1 promotes the progression of bladder cancer by regulating miR-4735-3p/NOTCH2 axis. |
External Links
| Links for ARAP1-AS1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |