Basic Information
| LncRNA/CircRNA Name | lnc_EGFR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | tongue cancer |
| ICD-0-3 | C02 |
| Methods | qPCR, Western blot |
| Sample | tongue cancer tissues, cell lines (CRL.7421, SCC.25, HSC-3, UM1 and CAL-27) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of Lnc-EGFR inhibited the clonogenic ability and cell viability of human tongue cancer cell lines UM1 and CAL-27, as evidenced by colony formation assays, and cell proliferation.Lnc-EGFR knockdown-mediated inhibition of clonogenic ability and cell viability was rescued by overexpression of EGFR by adding EGFR recombinant protein into both cell lines.Lnc-EGFR knockdown-induced cell apoptosis was reversed by co-treatment with recombinant EGFR protein. |
| Pubmed ID | 29138845 |
| Year | 2017 |
| Title | Long noncoding RNA Lnc-EGFR promotes cell proliferation and inhibits cell apoptosis via regulating the expression of EGFR in human tongue cancer. |
External Links
| Links for lnc_EGFR | GenBank HGNC NONCODE |
| Links for tongue cancer | OMIM COSMIC |