Basic Information
| LncRNA/CircRNA Name | LNAPPCC |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay etc |
| Sample | colon cancer tissues and matched adjacent normal tissues,cell line (NCM460,HT-29, SW620, HCT-15, and HCT116) |
| Expression Pattern | up-regulated |
| Function Description | Increased expression of LNAPPCC is positively associated with metastasis, recurrence, and poor survival of colon cancer patients.LNAPPCC promotes colon cancer cell proliferation, migration, and in vivo xenograft growth and liver metastasis. Mechanistic investigations revealed that LNAPPCC binds EZH2, represses the binding of EZH2 to PCDH7 promoter, downregulates histone H3K27me3 level in PCDH7 promoter, and activates PCDH7 expression. |
| Pubmed ID | 32330872 |
| Year | 2020 |
| Title | Recurrence-Associated Long Non-coding RNA LNAPPCC Facilitates Colon Cancer Progression via Forming a Positive Feedback Loop with PCDH7. |
External Links
| Links for LNAPPCC | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |