Basic Information
| LncRNA/CircRNA Name | LMCD1-AS1 |
| Synonyms | NA |
| Region | GRCh38_3:7952805-8611924 |
| Ensemble | ENSG00000227110 |
| Refseq | NR_033378 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | osteosarcoma tissues,cell lines (SW1353, SaOS2, MG63 and U2OS) |
| Expression Pattern | up-regulated |
| Function Description | Moreover, we showed that SP1 can bind to the promoter region of LMCD1-AS1, resulting in its overexpression in osteosarcoma. Functionally, silencing of LMCD1-AS1 suppressed the proliferation, migration, invasion and EMT progress of osteosarcoma cells. Mechanistic studies revealed that LMCD1-AS1 was a sponge of miR-106b-5p activity. LMCD1-AS1 modulated survival of osteosarcoma via targeting miR-106b-5p. Overall, we firstly indicated that LMCD1-AS1 overexpression contributes to osteosarcoma development and poor clinical outcome, suggesting that LMCD1-AS1 may be a novel diagnostic and prognostic biomarker for osteosarcoma and a target for osteosarcoma therapy. |
| Pubmed ID | 32248969 |
| Year | 2020 |
| Title | SP1-mediated Upregulation of lncRNA LMCD1-AS1 Functions a ceRNA for miR-106b-5p to Facilitate Osteosarcoma Progression |
External Links
| Links for LMCD1-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |