Basic Information
| LncRNA/CircRNA Name | LINP1 |
| Synonyms | NA |
| Region | GRCh38_10:6737382-6739026 |
| Ensemble | ENSG00000223784 |
| Refseq | NR_138480 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot, Northern blot, RIP, RNA pull-down assay etc. |
| Sample | cell lines (MDA-MB-231, MDA-MB-468, MCF7, HCT116 WT and HCT116 TP53) |
| Expression Pattern | up-regulated |
| Function Description | LINP1, which is overexpressed in human triple-negative breast cancer. We found that LINP1 enhances repair of DNA double-strand breaks by serving as a scaffold linking Ku80 and DNA-PKcs, thereby coordinating the NHEJ pathway. Importantly, blocking LINP1, which is regulated by p53 and epidermal growth factor receptor (EGFR) signaling, increases the sensitivity of the tumor-cell response to radiotherapy in breast cancer. |
| Pubmed ID | 27111890 |
| Year | 2016 |
| Title | Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. |
External Links
| Links for LINP1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |