Basic Information
| LncRNA/CircRNA Name | LINP1 |
| Synonyms | NA |
| Region | GRCh38_10:6737382-6739026 |
| Ensemble | ENSG00000223784 |
| Refseq | NR_138480 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | wilms tumor |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot |
| Sample | Tumor samples and adjacent tissues |
| Expression Pattern | up-regulated |
| Function Description | LINP1 expression level in Wilms` tumor tissues was significantly higher than that of adjacent tissues. LINP1 expression was negatively associated with the overall survival time of patients with Wilms` tumor. Cell growth ability was markedly inhibited and promoted after down-regulation and overexpression of LINP1 in vitro, respectively. Moreover, after the loss and gain of LINP1 in vitro, cell migration and invasion abilities were remarkably repressed and promoted, respectively. Furthermore, the loss of LINP1 in vitro could significantly decrease the expressions of targeted proteins in the Wnt/?-catenin signaling pathway. However, the expressions of targeted proteins in the Wnt/?-catenin signaling pathway were remarkably up-regulated after over-expression of LINP1. |
| Pubmed ID | 31298321 |
| Year | 2019 |
| Title | Long non-coding RNA LINP1 induces tumorigenesis of Wilms` tumor by affecting Wnt/?-catenin signaling pathway |
External Links
| Links for LINP1 | GenBank HGNC NONCODE |
| Links for wilms tumor | OMIM COSMIC |