Basic Information
| LncRNA/CircRNA Name | LINP1 |
| Synonyms | NA |
| Region | GRCh38_10:6737382-6739026 |
| Ensemble | ENSG00000223784 |
| Refseq | NR_138480 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | RNA-seq, qPCR, Western blot |
| Sample | KG-1 and THP-1 leukemia cells, bone marrow |
| Expression Pattern | up-regulated |
| Function Description | LINP1 was significantly overexpressed in AML patients at diagnosis, whereas down-regulated after complete remission (CR). Furthermore, knockdown of LINP1 expression remarkably suppressed glucose uptake and AML cell maintenance. Mechanistically, LINP1 was found to inhibit the glucose metabolism by suppressing the expression of HNF4a. Both LINP1 and HNF4a knockdown reduced the expression levels of AMPK phosphorylation and WNT5A, indicating for the first time that LINP1 strengthened the HNF4a-AMPK/WNT5A signaling pathway involved in cell glucose metabolism modulation and AML cell survival. |
| Pubmed ID | 31325181 |
| Year | 2019 |
| Title | LncRNA LINP1 regulates acute myeloid leukemia progression via HNF4?/AMPK/WNT5A signaling pathway |
External Links
| Links for LINP1 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |