Basic Information
| LncRNA/CircRNA Name | LINP1 |
| Synonyms | NA |
| Region | GRCh38_10:6737382-6739026 |
| Ensemble | ENSG00000223784 |
| Refseq | NR_138480 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR, Western blot analysis |
| Sample | OC tissues,cell lines A2780, OVCAR-3, and SKOV3 and ISOE80 |
| Expression Pattern | up-regulated |
| Function Description | LINP1 expression was remarkably higher in ovarian carcinoma samples compared with adjacent tissues. Moreover, cell proliferation, migration, and invasion were inhibited after LINP1 was silenced in the ovarian cancer cells. Besides, the messenger (mRNA) and the protein of KLF6 were overexpressed after LINP1 was silenced. Furthermore, the KLF6 expression level was negatively related to the LINP1 expression level in ovarian cancer samples. |
| Pubmed ID | 31957816 |
| Year | 2020 |
| Title | Long Noncoding RNA LINP1 Promoted Proliferation and Invasion of Ovarian Cancer via Inhibiting KLF6 |
External Links
| Links for LINP1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |