Basic Information
| LncRNA/CircRNA Name | LINP1 |
| Synonyms | NA |
| Region | GRCh38_10:6737382-6739026 |
| Ensemble | ENSG00000223784 |
| Refseq | NR_138480 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RT-PCR, Western blot analysis |
| Sample | GC tissues,cell lines (MKN45, SGC-7901, BGC-823 ,GES) |
| Expression Pattern | up-regulated |
| Function Description | LINP1 expression was remarkably up-regulated in GC tissues compared with adjacent normal tissues. The growth ability of GC cells was significantly inhibited after silencing of LINP1 in vitro. Besides, the apoptosis of GC cells was markedly induced after silencing of LINP1. The silence of LINP1 significantly up-regulated the expression of RBM5 in GC cells. knockdown of LINP1 markedly inhibited tumor formation in vivo. |
| Pubmed ID | 31957826 |
| Year | 2020 |
| Title | LncRNA LINP1 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer Cells by Repressing RBM5 |
External Links
| Links for LINP1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |