Basic Information
| LncRNA/CircRNA Name | LINK-A |
| Synonyms | LINC01139, LINK-A, LINKA |
| Region | GRCh38_1:238480384-238486023 |
| Ensemble | ENSG00000215808 |
| Refseq | NR_015407 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Cell transfection, Fluorescence quenching assay, Lipid-RNA pulldown assay etc. |
| Sample | TNBC tissues, cell lines (MDA-MB-231, MDA-MB-468, MCF-10A) |
| Expression Pattern | differential expression |
| Function Description | LINK-A directly interacts with the AKT pleckstrin homology domain and PIP3 at the single-nucleotide level, facilitating AKT-PIP3 interaction and consequent enzymatic activation. LINK-A-dependent AKT hyperactivation leads to tumorigenesis and resistance to AKT inhibitors. Genomic deletions of the LINK-A PIP3-binding motif dramatically sensitized breast cancer cells to AKT inhibitors. |
| Pubmed ID | 28218907 |
| Year | 2017 |
| Title | The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors. |
External Links
| Links for LINK-A | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |