Basic Information
| LncRNA/CircRNA Name | LINK-A |
| Synonyms | NA |
| Region | GRCh38_1:238480384-238486023 |
| Ensemble | ENSG00000215808 |
| Refseq | NR_015407 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | mantle cell lymphoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | Human mantle cell lymphoma cell lines JVM-2 and Z-138 |
| Expression Pattern | up-regulated |
| Function Description | compared with healthy controls, plasma levels of LINK-A lncRNA and survivin were significantly increased in patients with mantle cell lymphoma. Upregulation of LINK-A lncRNA sensitively distinguished patients with mantle cell lymphoma from healthy controls. Plasma levels of LINK-A lncRNA and survivin were positively correlated in mantle cell lymphoma patients but not in healthy controls. |
| Pubmed ID | 30636001 |
| Year | 2019 |
| Title | LINK-A lncRNA Promotes Proliferation and Inhibits Apoptosis of Mantle Cell Lymphoma Cell by Upregulating Survivin |
External Links
| Links for LINK-A | GenBank HGNC NONCODE |
| Links for mantle cell lymphoma | OMIM COSMIC |