Basic Information
| LncRNA/CircRNA Name | LINK-A |
| Synonyms | LINC01139, LINK-A, LINKA |
| Region | GRCh38_1:238480384-238486023 |
| Ensemble | ENSG00000215808 |
| Refseq | NR_015407 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, other |
| Sample | plasma, NSCLC cell lines (H1993, H1581) |
| Expression Pattern | up-regulated |
| Function Description | Plasma levels of LINK-A were found to be significantly higher in patients with different types of metastatic NSCLC than in patients with non-metastatic NSCLC and healthy controls. Plasma levels of LINK-A were lower in patients with metastatic NSCLC on the day of discharge than on the day of admission. Patients with high plasma LINK-A had a higher mortality rate and lower progression-free survival rate within 2 years of discharge. In conclusion, LINK-A is overexpressed in metastatic NSCLC, and may promote the migration and invasion of NSCLC by activating Akt signaling. |
| Pubmed ID | 31404323 |
| Year | 2019 |
| Title | LINK-A lncRNA Is Upregulated in Metastatic Non-Small Cell Lung Cancer and Is Associated With Poor Prognosis |
External Links
| Links for LINK-A | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |