Basic Information
| LncRNA/CircRNA Name | LINK-A |
| Synonyms | LINC01139, LINK-A, LINKA |
| Region | GRCh38_1:238480384-238486023 |
| Ensemble | ENSG00000215808 |
| Refseq | NR_015407 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RNAi, other |
| Sample | glioma cell lines( CCD-25Lu and Hs 683), blood |
| Expression Pattern | up-regulated |
| Function Description | Increased levels of LINK-A lncRNA distinguished glioma patients from healthy controls, based on ROC curve analysis. Serum levels of LINK-A lncRNA and survivin were positively correlated in glioma patients, but not in healthy controls. Overexpression of LINK-A lncRNA led to increased survivin protein expression, while survivin overexpression had no effect on LINK-A lncRNA expression. LINK-A lncRNA and survivin overexpression each reduced glioma cell apoptosis, but LINK-A lncRNA siRNA-mediated knockdown increased apoptosis. Survivin overexpression attenuated the inducing effects of LINK-A lncRNA knockdown on apoptosis. In conclusion, LINK-A lncRNA inhibited glioma cell apoptosis potentially by the upregulation of survivin. |
| Pubmed ID | 31410112 |
| Year | 2019 |
| Title | LINK-A lncRNA Participates in the Pathogenesis of Glioma by Interacting With Survivin |
External Links
| Links for LINK-A | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |