Basic Information
| LncRNA/CircRNA Name | LINK-A |
| Synonyms | NA |
| Region | GRCh38_1:238480384-238486023 |
| Ensemble | ENSG00000215808 |
| Refseq | NR_015407 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot |
| Sample | blood, cell lines (UWB1.289, UWB1.289+BRCA1 ) |
| Expression Pattern | up-regulated |
| Function Description | We found that LINK-A and TGF-?1 were up-regulated in ovarian carcinoma patients than in healthy controls. Plasma levels of LINK-A were positively correlated with plasma TGF-?1 in ovarian carcinoma patients but not in healthy controls. Plasma levels of LINK-A were correlated with distant tumor metastasis but not tumor size. |
| Pubmed ID | 30061183 |
| Year | 2018 |
| Title | LINK-A lncRNA Promotes Migration and Invasion of Ovarian Carcinoma Cells by Activating TGF-? Pathway. |
External Links
| Links for LINK-A | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |