Basic Information
| LncRNA/CircRNA Name | LINK-A |
| Synonyms | NA |
| Region | GRCh38_1:238480384-238486023 |
| Ensemble | ENSG00000215808 |
| Refseq | NR_015407 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic adenocarcinoma |
| ICD-0-3 | NA |
| Methods | qRT-qPCR, Western blot |
| Sample | pancreatic adenocarcinoma cell lines,blood |
| Expression Pattern | up-regulated |
| Function Description | Silencing of LINK-A led to inhibition of pancreatic adenocarcinoma cell proliferation, migration and invasion. Simultaneous overexpression of ROCK1 attenuated the inhibitory effect of LINK-A silencing on cancer cell proliferation, migration and invasion. Overexpression of LINK-A lncRNA led to upregulation of ROCK1 expression, while overexpression of ROCK1 had no significant effect on LINK-A lncRNA expression. |
| Pubmed ID | 32104251 |
| Year | 2020 |
| Title | LncRNA LINK-A regulates ROCK1 expression in early-stage pancreatic adenocarcinoma |
External Links
| Links for LINK-A | GenBank HGNC NONCODE |
| Links for pancreatic adenocarcinoma | OMIM COSMIC |