Basic Information
| LncRNA/CircRNA Name | LINC-USP16 |
| Synonyms | NA |
| Region | GRCh38_21:29024629-29054488 |
| Ensemble | ENSG00000156256 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot |
| Sample | cell lines (MHCC97H, MHCC97L, HepG2, SMMC-7721, and LO2) |
| Expression Pattern | down-regulated |
| Function Description | Linc-USP16 expression was significantly down-regulated in HCC patient tissues and cell lines. Further functional experiments suggested that Linc-USP16 could directly increase PTEN expression by acting as a competing endogenous RNA (ceRNA) for miR-21 and miR-590-5p. |
| Pubmed ID | 29179215 |
| Year | 2017 |
| Title | Long Non-Coding RNA Linc-USP16 Functions As a Tumour Suppressor in Hepatocellular Carcinoma by Regulating PTEN Expression |
External Links
| Links for LINC-USP16 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |