Basic Information
| LncRNA/CircRNA Name | LINC-UFC1 |
| Synonyms | UFC1, HSPC155 |
| Region | GRCh38_1:161152776-161158856 |
| Ensemble | ENSG00000143222 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | Human GC cell lines MGC-803, BGC-823, SGC-7901, HGC-27, MKN-45, GES-1, BGC-823, SGC-7901, MKN-45cells. tumor tissues, non-tumor tissues. |
| Expression Pattern | up-regulated |
| Function Description | UFC1 has a promoting role in GC progression, at least in part, by acting as a miR-498 sponge and derepressing Lin28b expression, which would provide a novel biomarker for GC diagnosis and prognosis and offer a potential target for GC therapy.Suppression of Lin28b by miR-498 could be rescued by UFC1 overexpression, whereas Lin28b overexpression partially rescued UFC1 knockdown-mediated inhibition of GC cell function. Lin28b expression was increased in GC and suggested a co-expression pattern with UFC1. The circulating lncRNAs provide a blood-based biomarker for cancer detection.Survival time was analyzed by Kaplan-Meier method and log-rank test. P values less than 0.05 was considered statistically significant.The circulating lncRNAs provide a blood-based biomarker for cancer detection. |
| Pubmed ID | 29970131 |
| Year | 2018 |
| Title | Long non-coding RNA UFC1 promotes gastric cancer progression by regulating miR-498/Lin28b. |
External Links
| Links for LINC-UFC1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |