Basic Information
| LncRNA/CircRNA Name | LINC-UBC1 |
| Synonyms | BLACAT1, LINC00912, linc-UBC1, onco-lncRNA-30 |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi etc. |
| Sample | gastric cancer tissues, cell lines (BGC-823, SGC-7901, AGS, MKN-45, HGC-27 etc.) |
| Expression Pattern | up-regulated |
| Function Description | We found that linc-UBC1 was significantly upregulated in gastric cancer tissues compared to adjacent normal tissues. Furthermore, high linc-UBC1 expression was associated with lymph-node metastasis, tumor size, TNM stage and poorer prognosis. Inhibition of linc-UBC1 suppressed the proliferation, motility and invasion of gastric cancer cells.Inhibition of linc-UBC1 suppressed the proliferation, motility and invasion of gastric cancer cells. |
| Pubmed ID | 25755750 |
| Year | 2015 |
| Title | Long noncoding RNA linc-UBC1 is negative prognostic factor and exhibits tumor pro-oncogenic activity in gastric cancer. |
External Links
| Links for LINC-UBC1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |