Basic Information
| LncRNA/CircRNA Name | LINC-UBC1 |
| Synonyms | BLACAT1, LINC00912, linc-UBC1, onco-lncRNA-30 |
| Region | GRCh38_1:205434886-205437879 |
| Ensemble | ENSG00000281406 |
| Refseq | NR_103783 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | CRC tissues, cell lines (SW480, HCT116, HT29, and SW620) |
| Expression Pattern | up-regulated |
| Function Description | linc-UBC1 was significantly overexpressed in CRC tissues and the majority of CRC cell lines compared with the matched non-tumor mucosa and normal intestinal epithelial cells. The results also revealed that reducing the expression of linc-UBC1 led to the inhibition of migration, invasion, and proliferation of CRC cells in vitro. |
| Pubmed ID | 28260919 |
| Year | 2017 |
| Title | Overexpression of the long non-coding RNA, linc-UBC1, is associated with poor prognosis and facilitates cell proliferation, migration, and invasion in colorectal cancer. |
External Links
| Links for LINC-UBC1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |