Basic Information
| LncRNA/CircRNA Name | LINC-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 |
| Ensemble | ENSG00000258609 |
| Refseq | NR_048536 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR |
| Sample | breast cancer tissues, cell lines (MCF-7, MDA-MB-231, SK-BR-3, BT549, MCF10A) |
| Expression Pattern | up-regulated |
| Function Description | Plasma lincRNA-ROR levels were associated with estrogen receptors and lymph node metastasis.Plasma lincRNA-ROR may be a potential biomarker for BC diagnosis and a dynamic monitor.LincRNA-ROR is reportedly overexpressed in triple-negative (ER-, PR-, HER2-) breast cancer and could serve as a biomarker or therapeutic target for improving survival. |
| Pubmed ID | 29090518 |
| Year | 2017 |
| Title | Detection and analysis of circulating large intergenic non-coding RNA regulator of reprogramming in plasma for breast cancer. |
External Links
| Links for LINC-ROR | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |