Basic Information
| LncRNA/CircRNA Name | LINC-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 |
| Ensemble | ENSG00000258609 |
| Refseq | NR_048536 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (MCF10A, MCF7, MDA-MB-231, HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | Compared with immortalized MCF10A breast epithelial cells, lncRNA-ROR was highly expressed in MCF7 (nonresistant) and MDA-MB-231 (drug-resistant) cell lines. The lncRNA-ROR level was strongly elevated in the MDA-MB-231 cell line as compared to the MCF7 cell line, indicating that lncRNA-ROR can be involved in the development of breast cancer. |
| Pubmed ID | 28063065 |
| Year | 2017 |
| Title | Effects of long noncoding RNA-ROR on tamoxifen resistance of breast cancer cells by regulating microRNA-205. |
External Links
| Links for LINC-ROR | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |