Basic Information
| LncRNA/CircRNA Name | APTR |
| Synonyms | APTR, RSBN1L-AS1 |
| Region | GRCh38_7:77657660-77696265 |
| Ensemble | ENSG00000214293 |
| Refseq | NR_038361 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Northern blot, Luciferase reporter assay etc. |
| Sample | primary glioblastoma tissues, cell lines (A172, HCT116) |
| Expression Pattern | up-regulated |
| Function Description | We identified a novel lncRNA, APTR, that acts in trans to repress the CDKN1A/p21 promoter independent of p53 to promote cell proliferation. |
| Pubmed ID | 24748121 |
| Year | 2014 |
| Title | A new lncRNA, APTR, associates with and represses the CDKN1A/p21 promoter by recruiting polycomb proteins. |
External Links
| Links for APTR | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |