Basic Information
| LncRNA/CircRNA Name | APTR |
| Synonyms | RSBN1L-AS1 |
| Region | GRCh38_7:77657660-77696265 |
| Ensemble | ENSG00000214293 |
| Refseq | NR_038361 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | OS tissues and cell lines (MG63, 143B, Saos-2, and HOS) |
| Expression Pattern | up-regulated |
| Function Description | In functional terms, knockdown of APTR and overexpression of miR-132-3p both, remarkably repressed human OS cell proliferation, invasion and migration, and induced apoptosis. Also, Yes-associated protein 1 (YAP1) was determined as an inhibitory target of miR-132-3p. Moreover, our findings demonstrated that the repression of YAP1 protein expression and the suppression of Ki-67, MMP9, and Bcl2 expression induced by APTR knockdown required increased miR-132-3p. Thus, APTR contributed to OS progression through repression of miR-132-3p and upregulation of YAP1 expression. |
| Pubmed ID | 30317613 |
| Year | 2019 |
| Title | Long Noncoding RNA APTR Contributes to Osteosarcoma Progression Through Repression of miR-132-3p and Upregulation of Yes-Associated Protein 1 |
External Links
| Links for APTR | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |