Basic Information
| LncRNA/CircRNA Name | LINC-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 |
| Ensemble | ENSG00000258609 |
| Refseq | NR_048536 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, RIP |
| Sample | ESCC tumor tissues, EC cell lines (EC109 and EC9706) |
| Expression Pattern | up-regulated |
| Function Description | ROR expression in ESCC tumor tissues was significantly higher than in the adjacent tissues.The survival rate of ESCC patients with high ROR expression levels was lower than that of patients with low ROR expression levels.ROR overexpression could downregulate miR-145 by up to 50% was proven by RIP,DLR assay,and qRT-PCR.FSCN1 was a downstream target of ROR/miR-145.Transwell assays were used to show that overexpression of ROR enhanced migration and invasion behavior of ESCC and miR-145 hindered these effects. |
| Pubmed ID | 29430188 |
| Year | 2018 |
| Title | LincRNA-ROR promotes metastasis and invasion of esophageal squamous cell carcinoma by regulating miR-145/FSCN1. |
External Links
| Links for LINC-ROR | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |