Basic Information
| LncRNA/CircRNA Name | LINC-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 |
| Ensemble | ENSG00000258609 |
| Refseq | NR_048536 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay etc. |
| Sample | nasopharyngeal carcinoma tissues, cell lines (CNE2, CNE1, 5-8F, 6-18B) |
| Expression Pattern | up-regulated |
| Function Description | We found that lncRNA-ROR was significantly upregulated in NPC tissues compared with normal tissues. Next, our study proved that lncRNA-ROR was highly associated with the proliferation, metastasis and apoptosis of NPC. The enrichment of lncRNA-ROR played a critucal functional role in chemoresistance. The mechanism by which NPC resists chemotherapy might be that lncRNA-ROR suppress p53 signal pathway. |
| Pubmed ID | 27311700 |
| Year | 2016 |
| Title | Long non-coding RNA ROR promotes proliferation, migration and chemoresistance of nasopharyngeal carcinoma. |
External Links
| Links for LINC-ROR | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |