Basic Information
| LncRNA/CircRNA Name | LINC-ROR |
| Synonyms | LINC-ROR, ROR, lincRNA-RoR |
| Region | GRCh38_18:57054558-57072119 |
| Ensemble | ENSG00000258609 |
| Refseq | NR_048536 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | The human hepatocellular carcinoma cell lines, including HepG2, Huh7, SMMC -7721 and Bel -7402, The normal liver cell line LO2, HCC tissue samples and corresponding adjacent tissues |
| Expression Pattern | up-regulated |
| Function Description | Linc -ROR was enriched in exosomes released by HepG2 cells. Exosomes derived from HepG2 cells promoted the proliferation and suppressed the apoptosis of LO2 cells suffering nutrient deficiency. Knockdown the expression of Linc -ROR in HepG2 or LO2 cells could significantly impaired the exosomes ` effects on LO2 cells. In addition, the long -term coculture with exosomes would obviously change the biological behaviors of LO2 cells. |
| Pubmed ID | 31400406 |
| Year | 2019 |
| Title | Exosomes derived from liver cancer cells reprogram biological behaviors of LO2 cells by transferring Linc -ROR |
External Links
| Links for LINC-ROR | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |