Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, RNAi etc. |
| Sample | NSCLC tissues, cell lines (NCI-H23, NCI-H1299, HCC-44) |
| Expression Pattern | down-regulated |
| Function Description | LincRNA-p21 was down-regulated in tumor tissue, but no association was observed with TP53 mutational status. To explain the poor outcome of patients with high lincRNA-p21 expression, we studied the role of lincRNA-p21 in angiogenesis in vitro and observed a global downregulation in the expression of angiogenesis-related genes when lincRNA-p21 was inhibited. |
| Pubmed ID | 27496652 |
| Year | 2016 |
| Title | LincRNA-p21 Impacts Prognosis in Resected Non-Small Cell Lung Cancer Patients through Angiogenesis Regulation. |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |