Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay etc. |
| Sample | glioma tissues |
| Expression Pattern | down-regulated |
| Function Description | we found that lincRNA-p21 negatively regulated the expression and activity of B-catenin in GSCs. Downregulation of lincRNA-p21 in GSCs was resulted from upregulation of Hu antigen R (HuR) expression caused by miR-146b-5p downregulation. MiR-146b-5p overexpression increased apoptosis and radiosensitivity, decreased cell viability, neurosphere formation capacity and stem cell marker expression, and induced differentiation in GSCs. Moreover, knock-down lincRNA-p21 or HuR and B-catenin overexpression could rescue the phenotypic changes resulted from miR-146b-5p overexpression in GSCs |
| Pubmed ID | 27166258 |
| Year | 2016 |
| Title | MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA-p21/B-catenin pathway |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |