Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR etc. |
| Sample | cell lines (wt MEFs, NIH/3T3 MEFs etc.) |
| Expression Pattern | down-regulated |
| Function Description | Indeed, lincRNA-p21 overexpression in a lung cancer cell line harboring a KRAS mutation (referred to as LKR) and in NIH/3T3 MEFs caused a significant decrease in cell viability. This decrease in viability was due to increased apoptosis in response to DNA damage and not to an effect in cell cycle regulation. |
| Pubmed ID | 20673990 |
| Year | 2010 |
| Title | A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |