Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (SMMC7721, U251MG) |
| Expression Pattern | down-regulated |
| Function Description | In this work, we found that X-ray irradiation or hypoxia treatment elevated lincRNA-p21 expression in SMMC7721 hepatoma and U251MG glioma cells.High lincRNA-p21 levels were associated with poor cancer-specific survival in patients. F.. However, tumor cells can express a wide range of transcription factors, such as hypoxia-inducible factor-1a (HIF-1a).found that LincRNA-p21 was downregulated in non-small-cell lung cancer tissue, but no association was observed with TP53 mutational status. |
| Pubmed ID | 28689810 |
| Year | 2017 |
| Title | LincRNA-p21 knockdown enhances radiosensitivity of hypoxic tumor cells by reducing autophagy through HIF-1/Akt/mTOR/P70S6K pathway. |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |