Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | chronic lymphocytic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | blood |
| Expression Pattern | up-regulated |
| Function Description | We analyzed its expression in CLL and lymphoma in the context of DNA damage. 24 hours after IR, lincRNA-p21 expression was strongly induced in a p53-dependent manner in a very large set of CLL patients (n = 73).lncRNAs NEAT1 and lincRNA-p21 as novel elements of the p53-dependent DNA damage response machinery in CLL and lymphoma. |
| Pubmed ID | 25971364 |
| Year | 2015 |
| Title | p53-dependent non-coding RNA networks in Chronic Lymphocytic Leukemia. |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for chronic lymphocytic leukemia | OMIM COSMIC |