Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, etc. |
| Sample | Primary GC tissues, GC cell lines (AGS, MGC-803, HCG-27, and SGC7901) and gastric mucosa cell line (GES-1) |
| Expression Pattern | down-regulated |
| Function Description | the expression level of lincRNA p21 was downregulated in the GC tissues and cell lines. Moreover, ectopic expression of lincRNA p21 suppressed the GC cell growth, cell cycle, and migration. Furthermore, we demonstrated that the X ray increased the expression level of lincRNA p21 in both the HCG 27 and SGC7901 cells and elevated expression of lincRNA p21 increased the radiotherapy sensitivity of the GC cell. In addition, we showed that ectopic expression of lincRNA p21 suppressed the ? catenin and c myc expression. Overexpression of lincRNA p21 inhibited the GC cell proliferation and increased the radiosensitivity of GC cells by regulating the ? catenin signaling pathway. These data suggested that lincRNA p21 acted as a tumor suppressor gene in the development of GC. |
| Pubmed ID | 30484893 |
| Year | 2018 |
| Title | LincRNA-p21 enhances the sensitivity of radiotherapy for gastric cancer by targeting the ?-catenin signaling pathway |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |