Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR , Western blot etc. |
| Sample | MHCC97H liver cancer cell line |
| Expression Pattern | up-regulated |
| Function Description | Compared with that in control group, the lincRNA-p21 mRNA level in observation group was increased significantly .HIF-1? was one of the targets of lincRNA-p21. lincRNA-p21 can significantly downregulate the level of HIF-1?, thus downregulating the expression of VEGF and affecting the cell proliferation, apoptosis and migration. |
| Pubmed ID | 31186706 |
| Year | 2019 |
| Title | Effect of lincRNA-p21 Targeting HIF-1? on Biological Functions of Liver Cancer Cells |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |