Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | glioma cell lines (U87 and U251) |
| Expression Pattern | up-regulated |
| Function Description | CRF could suppress the proliferation of glioma cells and promote the expression of lincRNA-p21. Afterwards, lincRNA-p21 repressed the proliferation and invasion of glioma cells, which was reversed by miR-34c targeted with 3'-UTR. Furthermore, miR-34c decreased the expression of CRFR1 by binding with the 3'-UTR, which interact with CRF to inhibit the proliferation of glioma cells. |
| Pubmed ID | 29981322 |
| Year | 2018 |
| Title | Corticotropin-releasing Factor Suppresses Glioma Progression by Upregulation of Long Non-Coding RNA-p21 |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |