Basic Information
| LncRNA/CircRNA Name | LINCRNA-APOC1P1-3 |
| Synonyms | APOC1P1 |
| Region | GRCh38_19:44926804-44931386 |
| Ensemble | ENSG00000214855 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, qPCR, RNAi, RNA pull-down assay etc. |
| Sample | breast cancer tissues, cell lines (MCF7, MDA-MB-231, MDA-MB-453, MDA-MB-468) |
| Expression Pattern | up-regulated |
| Function Description | The lincRNA-APOC1P1-3 was overexpressed in breast cancer, which was related to tumor size and hypomethylation in its promoter region. We also found that APOC1P1-3 could directly bind to tubulin to decrease a-tubulin acetylation, to inactivate caspase-3, and to inhibit apoptosis. |
| Pubmed ID | 27228351 |
| Year | 2016 |
| Title | Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing a-tubulin acetylation in breast cancer. |
External Links
| Links for LINCRNA-APOC1P1-3 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |