Basic Information
| LncRNA/CircRNA Name | LINC-PINT |
| Synonyms | NA |
| Region | GRCh38_7:130938963-131110176 |
| Ensemble | ENSG00000231721 |
| Refseq | NR_015431 |
| Regulatory Mechanism | Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | cisplatin | |
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Information of Cancer
| Cancer Name | laryngeal cancer |
| ICD-0-3 | C32 |
| Methods | qRT-PCR, Western blot analysis etc. |
| Sample | laryngeal carcinoma and paired adjacent normal tissues, Human type-2 epithelial cells (HEp-2) |
| Expression Pattern | down-regulated |
| Function Description | LINC-PINT expression was downregulated in laryngeal tumors. LINC-PINT targeted miR-425-5p by three sites. miR-425-5p also targeted PTCH1 a protein of the Hedgehog pathway. Downregulation of LINC-PINT was associated with increased cancer stemness and chemoresistance to cisplatin. |
| Pubmed ID | 31131448 |
| Year | 2019 |
| Title | Long noncoding RNA LINC-PINT regulates laryngeal carcinoma cell stemness and chemoresistance miR-425-5p/PTCH1/SHH axis |
External Links
| Links for LINC-PINT | GenBank HGNC Noncode |
| Links for laryngeal cancer | Omim Cosmic |