Basic Information
| LncRNA/CircRNA Name | LINC-POU3F3 |
| Synonyms | POU3F3, BRN1, OTF8, brain-1, oct-8 |
| Region | GRCh38_2:104855511-104858574 |
| Ensemble | ENSG00000198914 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | exosome | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, etc. |
| Sample | hepatocellular carcinoma tissues, cell lines (Li-7, HepG2, SNU-449, Bel-7402) |
| Expression Pattern | up-regulated |
| Function Description | linc-POU3F3 expression significantly promoted tumor cell proliferation, migration and invasion. In addition, linc-POU3F3 expression was negatively correlated with POU3F3 mRNA and protein expressions in hepatocellular carcinoma tissues, and negatively regulated POU3F3 mRNA and protein expressions in hepatocellular carcinoma cells.Patients with linc-POU3F3 high-expression have shorter survival time than those with lowexpression of linc-POU3F3. |
| Pubmed ID | 29906746 |
| Year | 2018 |
| Title | Linc-POU3F3 is overexpressed in hepatocellular carcinoma and regulates cell proliferation, migration and invasion. |
External Links
| Links for LINC-POU3F3 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |