Basic Information
| LncRNA/CircRNA Name | LINC-PINT |
| Synonyms | LINC-PINT, LincRNA-Pint, MKLN1-AS1, PINT |
| Region | GRCh38_7:130938963-131110176 |
| Ensemble | ENSG00000231721 |
| Refseq | NR_015431 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Microarray, qPCR, RIP etc. |
| Sample | cell lines (KrasLA2/+, Trp53LSL/LSL, Rosa26-CreERT2 etc.) |
| Expression Pattern | down-regulated |
| Function Description | In this study, we have identified and characterized the lincRNA named Pint, abona fidep53 transcriptional target that acts as negative modulator of the p53 response.We found a significant downregulation of PINT in colorectal tumors compared with normal tissue, suggesting a potential role of the lincRNA as a tumor suppressor. Pint binds directly to PRC2, and is required for the targeting of PRC2 to specific genes for H3K27 tri-methylation and repression. Of the total number of genes affected by Pint inhibition, 39% were upregulated and 61% downregulated upon Pint knockdown. |
| Pubmed ID | 24070194 |
| Year | 2014 |
| Title | Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2. |
External Links
| Links for LINC-PINT | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |