Search Result

Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	gastric cancer
ICD-0-3	C16
Methods	qPCR, Luciferase reporter assay, etc.
Sample	gastric cancer tissue, Cells of AGS and SNU-1 cell lines
Expression Pattern	down-regulated
Function Description	lncRNA LINC PINT was downregulated, while microRNA 21 (miR 21) was upregulated in tumor tissues than in adjacent healthy tissues of gastric cancer patients. A significant and inverse correlation between expression levels of lncRNA LINC PINT and miR 21 was found in both tumor tissues and adjacent healthy tissues. The low expression level of LINCPINT and high expression level of the miR 21 tumor were correlated with poor prognosis. LINC PINT overexpression casued miR 21 inhibition in cells of human gastric cancer cell lines, while miR 21 overexpression did not alter LINC PINT expression. LINC PINT overexpression led to inhibited, while miR 21 overexpression led to promoted proliferation, migration, and invasion of gastric cancer cells. Effects of LINC PINT overexpression on cellular behaviors of gastric cancer cells were attenuated by miR 21 overexpression. Therefore, LINC PINT may participate in gastric cancer through the crosstalk with miR 21.
Pubmed ID	30569513
Year	2018
Title	Long noncoding RNA LINC-PINT is inhibited in gastric cancer and predicts poor survival

External Links