Basic Information
| LncRNA/CircRNA Name | LINC-PINT |
| Synonyms | LINC-PINT, LincRNA-Pint, MKLN1-AS1, PINT |
| Region | GRCh38_7:130938963-131110176 |
| Ensemble | ENSG00000231721 |
| Refseq | NR_015431 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR, other |
| Sample | melanoma tissues and cell lines (A375-, A375-MA2) |
| Expression Pattern | down-regulated |
| Function Description | Expression levels of LINC-PINT decreased, while expression levels of BANCR increased with increasing tumor thickness. The expression levels of LINC-PINT and BANCR were inversely associated in melanoma tissues but not in healthy adjacent tissue. LINC-PINT overexpression downregulated BANCR expression in melanoma cells, while BANCR overexpression did not significantly affect LINC-PINT expression. LINC-PINT overexpression inhibited melanoma cell proliferation in vitro compared to controls. BANCR overexpression attenuated the effects of LINC-PINT overexpression. |
| Pubmed ID | 31452772 |
| Year | 2019 |
| Title | lncRNA LINC-PINT Is Downregulated in Melanoma and Regulates Cell Proliferation by Downregulating lncRNA BANCR |
External Links
| Links for LINC-PINT | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |