Basic Information
| LncRNA/CircRNA Name | AP000439.3 |
| Synonyms | NA |
| Region | GRCh38_11:69475567-69481545 |
| Ensemble | ENSG00000255980 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR etc. |
| Sample | cell lines (MCF7, ZR-75-1, T47D) |
| Expression Pattern | up-regulated |
| Function Description | Silencing one of most prominent lncRNA, AP000439.3, resulted in inhibition of cell cycle progression and proliferation. Further study revealed AP000439.3 can regulate expression of CCND1 through enhancing estrogen receptor induction of CCND1. This fnding revealed lncRNAs may serve as important effectors of ER in regulation of gene expression and cell phenotype in breast cancer. |
| Pubmed ID | 29048636 |
| Year | 2017 |
| Title | Genome-wide study of ER-regulated lncRNAs shows AP000439.3 may function as a key regulator of cell cycle in breast cancer |
External Links
| Links for AP000439.3 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |