Basic Information
| LncRNA/CircRNA Name | LINC-ITGB1 |
| Synonyms | ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB |
| Region | GRCh38_10:32900319-33005792 |
| Ensemble | ENSG00000150093 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-231, MCF-7, T47D, ZR-75-30, 1590 etc.) |
| Expression Pattern | up-regulated |
| Function Description | The expression of linc-ITGB1 was significantly upregulated in both clinical breast cancer tissues and cultured breast cancer cell lines. Linc-ITGB1 depletion caused cell accumulation in the G0/G1 phase. Furthermore, the linc-ITGB1 knockdown decreased the expression of mesenchymal markers N-cadherin and vimentin while increasing the expression of the epithelial marker E-cadherin. Key cell cycle regulators Cdc25C and Cyclin B1 were also decreased by the linc-ITGB1 knockdown. These data suggest that linc-ITGB1 promotes breast cancer progression by inducing cell-cycle arrest and interrupting the epithelial-to-mesenchymal transition (EMT) process. |
| Pubmed ID | 26601916 |
| Year | 2015 |
| Title | Long non-coding RNA linc-ITGB1 promotes cell migration and invasion in human breast cancer. |
External Links
| Links for LINC-ITGB1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |