Basic Information
| LncRNA/CircRNA Name | LINC-GPR65-1 |
| Synonyms | NA |
| Region | GRCh39_14:88005124-88014811 |
| Ensemble | ENSG00000140030 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell lines (GES-1, MKN-28, SGC-7901, HGC-27, NCI-N87, AGS, and BGC-823), gastric cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | Linc-GPR65-1 was significantly up-regulated in 50 gastric cancer tissues compared to the corresponding normal tissues. In addition, increased linc-GPR65-1 expression was associated with TNM stage (P = 0.037), tumor size (P = 0.024), distal metastasis (P = 0.023), and poor prognosis of gastric cancer patients. Moreover, functional assays indicated that decreased linc-GPR65-1 expression inhibited the aggressive phenotypes of gastric cancer cells, and enhanced linc-GPR65-1 expression resulted in the opposite phenomenon. These data showed that linc-GPR65-1, regulating the PTEN-AKT-slug signaling pathway, might act as a tumor promoter and serve as a novel target for gastric cancer prevention and therapy. |
| Pubmed ID | 29336198 |
| Year | 2018 |
| Title | Long non-coding RNA GPR65-1 is up-regulated in gastric cancer and promotes tumor growth through the PTEN-AKT-slug signaling pathway. |
External Links
| Links for LINC-GPR65-1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |