Basic Information
| LncRNA/CircRNA Name | LINC0638 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qPCR |
| Sample | A normal human skin cell line CCD-1059Sk and two human melanoma cell lines C32 and SK-MEL-28, Plasma and skin biopsy tissues |
| Expression Pattern | up-regulated |
| Function Description | LINC01638 lncRNA was significantly upregulated in patients with melanoma compared with the other two groups of patients, and upregulation of LINC01638 lncRNA distinguished patients with melanoma from patients with benign skin lesions and healthy controls. LINC01638 lncRNA expression was significantly associated with tumor size but not with other patient clinical data. Plasma levels of LINC01638 lncRNA were further increased during follow-up in patients with local recurrence but not in patients without recurrence. LINC01638 lncRNA overexpression promoted, while knockdown inhibited proliferation of cells of melanoma cell lines, C32 and SK-MEL-28, in vitro. The upregulation of LINC01638 lncRNA was likely associated with the local recurrence of melanoma following surgical resection. |
| Pubmed ID | 31289478 |
| Year | 2019 |
| Title | LINC0638 lncRNA is involved in the local recurrence of melanoma following surgical resection |
External Links
| Links for LINC0638 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |