Basic Information
| LncRNA/CircRNA Name | LINC02582 |
| Synonyms | NA |
| Region | GRCh38_18:73324941-73349878 |
| Ensemble | ENSG00000261780 |
| Refseq | NR_038340 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | breast cancer tissues ,cell lines(MCF-10A cells,MDA-MB-231, MCF-7, BT549, SKBR3, T47D, and BT474 cells) |
| Expression Pattern | NA |
| Function Description | We identified lncRNA LINC02582 as a target of miR-200c. Inhibition of LINC02582 expression increased radiosensitvity, while overexpression of LINC02582 promoted radioresistance.LINC02582 interacts with deubiquitinating enzyme ubiquitin specific peptidase 7 (USP7) to deubiquitinate and stabilize checkpoint kinase 1 (CHK1), a critical effector kinase in DNA damage response, thus promoting radioresistance.These findings identified LINC02582 as a downstream target of miR-200c linking miR-200c to CHK1, in which miR-200c increases radiosensitivity by downregulation of CHK1. |
| Pubmed ID | 31601781 |
| Year | 2019 |
| Title | Long Noncoding RNA LINC02582 Acts Downstream of miR-200c to Promote Radioresistance Through CHK1 in Breast Cancer Cells |
External Links
| Links for LINC02582 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |