Basic Information
| LncRNA/CircRNA Name | LINC02465 |
| Synonyms | NA |
| Region | GRCh38_4:129771659-129955368 |
| Ensemble | ENSG00000249618 |
| Refseq | NR_151713 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | GC tissues, normal gastric epithelial cells GES-1 and human gastric cancer cell lines, such as MGC-803, SGC7901, BGC-823 and AGS |
| Expression Pattern | up-regulated |
| Function Description | LINC02465, a novel recognized lncRNA, is upregulated and correlated with tumour size, tumour stage, lymph node metastasis and differentiation in gastric cancer. Besides, high LINC02465 level in GC patients is closely related to poor prognosis. Moreover, our findings reveal that LINC02465 silence suppresses cell proliferation and migration, invasion and EMT in vitro. Conversely, LINC02465 overexpression displays a completely opposite way. Meanwhile, LINC02465 inhibition also limits tumor growth in vivo. Mechanistically, LINC02465 inhibition inactivates PI3K/AKT signaling pathway and the activation of this pathway by 740Y-P reverses the inhibition effect of LINC02465 suppression on biological behaviors of GC cells. |
| Pubmed ID | 30632400 |
| Year | 2018 |
| Title | Knockdown of LINC02465 Suppresses Gastric Cancer Cell Growth and Metastasis Via PI3K/AKT Pathway. |
External Links
| Links for LINC02465 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |