Basic Information
| LncRNA/CircRNA Name | LINC02454 |
| Synonyms | NA |
| Region | GRCh38_12:65602869-65612997 |
| Ensemble | ENSG00000256268 |
| Refseq | NR_146529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | Microarray, etc. |
| Sample | 318 papillary thyroid carcinoma (PTC) tissues, 35 normal thyroid gland tissues. |
| Expression Pattern | Differential expression |
| Function Description | According to multivariate Cox analysis, the combination of two DEGs (METTL7B and KCTD16) and two DElncRNAs (LINC02454 and LINC02471) could predict the outcome in a more exact way. In conclusion, top DEGs and DElncRNAs could raise diagnosis of PTC in indeterminate FNAB specimens, and some could function as molecule biomarkers for tumor progression and prognosis. The prognostic role of these factors was examined via Kaplan-Meier method, and the log-rank test was conducted to contradistinguish survival time. |
| Pubmed ID | 29968931 |
| Year | 2018 |
| Title | Role of differentially expressed genes and long non-coding RNAs in papillary thyroid carcinoma diagnosis, progression, and prognosis. |
External Links
| Links for LINC02454 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |