Basic Information
| LncRNA/CircRNA Name | LINC02381 |
| Synonyms | NA |
| Region | GRCh38_12:54126098-54142493 |
| Ensemble | ENSG00000250742 |
| Refseq | NR_026656 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Western blot |
| Sample | colorectal cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | LINC02381 was down regulated in CRC tissues and also in different cancerous cell lines. LINC02381 overexpression was increased PTEN protein levels but decreased phospho-Akt levels. LINC02381 might have suppressive effects on human colorectal cancer tumorigenesis partly by regulating PI3K signaling pathway. |
| Pubmed ID | 32092325 |
| Year | 2020 |
| Title | Epigenetically silenced LINC02381 functions as a tumor suppressor by regulating PI3K-Akt signaling pathway |
External Links
| Links for LINC02381 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |