Basic Information
| LncRNA/CircRNA Name | LINC02163 |
| Synonyms | NA |
| Region | GRCh38_5:104079911-104105403 |
| Ensemble | ENSG00000251026 |
| Refseq | XR_001742526 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | gastric cancer tissues, cell lines (HGC-27 and MKN-28) |
| Expression Pattern | up-regulated |
| Function Description | The expression level of LINC02163 was elevated in GC cell lines and tissues. Knockdown of LINC02163 inhibited GC cells growth and invasion both in vitro and in vivo. Mechanismly, LINC02163 exerted as a ceRNA and negatively regulated miR-593-3p expression. In addition, FOXK1 was identified as a down-stream target of miR-593-3p. The miR-593-3p/FOXK1 axis mediated LINC02163's effect on GC. |
| Pubmed ID | 29893595 |
| Year | 2018 |
| Title | LINC02163 Regulates Growth and Epithelial-To-Mesenchymal Transition Phenotype via miR-593-3p/FOXK1 Axis in Gastric Cancer Cells |
External Links
| Links for LINC02163 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |