Basic Information
| LncRNA/CircRNA Name | AOC4P |
| Synonyms | AOC4P, AOC4, UPAT |
| Region | GRCh38_17:42865922-42874369 |
| Ensemble | ENSG00000260105 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastrointestinal stromal tumor |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, RNAi, other |
| Sample | GIST tissues and caell lines (GIST-T1 and GIST-882) |
| Expression Pattern | up-regulated |
| Function Description | It was revealed that cell proliferative migration and invasive ability in si AOC4P group was decreased than that in CN and si CT groups, and cell apoptosis in si AOC4P group was higher than that in si CT group. The results of Western blot demonstrated that the expression of TGF-?1, ZEB1, Vimentin, and Snail in si AOC4P group were lower than that in si CT and CN group, and the expression of E-cadherin in si AOC4P group was higher than that in si CT and CN group. |
| Pubmed ID | 30288061 |
| Year | 2018 |
| Title | Effect of Long Non-Coding RNA AOC4P on Gastrointestinal Stromal Tumor Cells |
External Links
| Links for AOC4P | GenBank HGNC NONCODE |
| Links for gastrointestinal stromal tumor | OMIM COSMIC |